Don’t just live with chronic sinusitis symptoms. Treat them with XHANCE.
The only FDA-approved medicine for adults with chronic rhinosinusitis without nasal polyps.

Medical Device Components Diagram
Detailed diagram of a nasal spray device showing four main components: The nosepiece at the top for nasal insertion, a flexible mouthpiece that uses your own breath to help deliver medicine into nasal passages, an indented grip section for secure handling, and the main bottle container at the bottom.
Device Components:
- Nosepiece: For nasal insertion
- Flexible Mouthpiece: Uses your breath to assist medicine delivery
- Indented Grip: For secure handling
- Bottle: Contains the medication
Prescribed online. Delivered to your home.
Is XHANCE right for you?
Check your symptoms—if you have at least 2 of these symptoms for 12 weeks (or more), you might have chronic sinusitis.
Stuffy nose
When your nasal passages are blocked, making it hard to breathe through your nose.
Facial pain or pressure
A common symptom of sinusitis that may worsen when bending forward.
Runny nose/nasal drip
Can include a runny nose or a drip down the back of the throat.
Reduction of sense of smell
This can happen when the mucous membranes in your nose are inflamed or blocked.
In clinical trials, patients experienced significant reduction in symptoms
Symptoms
Reductions after 4 weeks
Reductions after 12 weeks
XHANCE is the only medication proven to reduce the risk of chronic sinusitis flare-ups*
Sinusitis flare-ups are worsening of sinus symptoms that can require additional treatment (such as a doctor visit, antibiotics, and/or oral steroids).
*Reduction of risk was measured at 24 weeks and established with high dose (372 mcg twice daily) only. In two clinical studies using twice-daily dosing, flare-ups occurred in 15.7% of placebo users (41/187), 9.9% of XHANCE 186 mcg users (20/184), and 7.8% of XHANCE 372 mcg users (15/183).

Your breath helps deliver medicine high and deep into your nasal passages where chronic sinusitis occurs.
Unlike with other nasal sprays, you blow into XHANCE, instead of sniffing.

Get started with XHANCE
This link will take you to beyondMD for a 5-minute questionnaire, to be reviewed by a medical provider. These are independent providers; they are not paid by Optinose. You may be responsible to pay for a medical consultation (similar to an in-person office visit).
How to see if XHANCE is right for you
Complete a medical questionnaire
The first step toward relief is to fill out a short questionnaire to see if your symptoms are consistent with chronic sinusitis and if you are eligible for this program.
A beyondMD clinician will review your responses
A clinician must diagnose you with chronic sinusitis and determine if XHANCE is right for you.
Our pharmacy partner will check for coverage eligibility for XHANCE in this program
XHANCE is covered by most private health insurance.
If prescribed, our pharmacy partner will review your insurance information and apply any discounts you may be eligible for.
Eligible patients pay as little as $0 for your prescription*
Get XHANCE in 3 simple steps
*These offers are not valid for use by cash-paying patients or patients enrolled in Medicare, Medicaid, and TRICARE or other federal or state programs. Copay support and other offers are subject to quantity limitations. Maximum benefits per fill apply. Patient cost share may impact benefit and eligibility. Optinose® reserves the right to rescind, revoke, or amend this offer without notice. Click here for additional terms and conditions.
Complete a brief medical questionnaire
See if your symptoms are consistent with chronic sinusitis, and add your insurance & payment info.
What you’ll need:
Photo ID
Payment Card (for $29 consultation fee)
Insurance Information
Virtual medical provider assessment
No onsite visit—a licensed medical provider will determine if XHANCE is right for you (virtual assessment cost: $29.00).
Delivered to your home
If prescribed and covered by your insurance, our pharmacy partner will fill your prescription for XHANCE, and deliver it to your home.
XHANCE is the only FDA-approved medicine for adults with chronic rhinosinusitis without nasal polyps.
Frequently asked questions about XHANCE
Meet some members of the beyondMD medical team
Licensed medical providers will evaluate your symptoms, and make appropriate treatment decisions. These medical providers are independently owned and operated, and are not affiliated with Optinose. Optinose is not responsible for the medical care furnished through these medical providers.

Hollie Hall
Nurse Practitioner

John Bernard
MD, Medical Director

Angela Shannon
MD

Meghan McInnis
Nurse Practitioner
Get started with XHANCE
Complete a brief medical questionnaire—you’ll need your photo ID, insurance info & payment card.
Indications
XHANCE is a prescription medicine used to treat chronic rhinosinusitis with or without nasal polyps in adults. It is not known if XHANCE is safe and effective in children.
Important Safety Information
- Do not use XHANCE if you are allergic to fluticasone propionate or any of the ingredients in XHANCE. Get emergency medical care if you get any of these signs of a serious allergic reaction: rash, hives, swelling of your face, mouth, and tongue, breathing problems, or low blood pressure.
- XHANCE can cause nasal problems such as nosebleeds, crusting, sores, hole in the septum, and slow wound healing. You should not use XHANCE until your nose has healed if you have a sore on your nose, have had surgery on your nose, or if your nose is injured.
- XHANCE can cause eye problems including glaucoma and cataracts. You should have regular eye exams when using XHANCE. Call your doctor if you have vision changes while using XHANCE.
- XHANCE may increase the risk of infections and can make certain infections worse. Avoid contact with people who have a contagious disease such as chickenpox or measles while using XHANCE.
- XHANCE can cause reduced production of steroid hormones by your adrenal gland, resulting in tiredness, weakness, nausea and vomiting, and low blood pressure.
- XHANCE can weaken bones (osteoporosis).
- The most common side effects include: nosebleeds, sores (ulcers) in your nose, pain or swelling of your nose or throat, redness in your nose, nasal congestion, sinus infection and headache.
- Tell your medical provider about all your medical conditions and medications that you take. It is especially important to mention if you take antifungal or anti-HIV medicines as they may interact with XHANCE.
These are not all the side effects of XHANCE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Patient Information, Full Prescribing Information and Instructions for Use.
Indications
XHANCE is a prescription medicine used to treat chronic rhinosinusitis with or without nasal polyps in adults. It is not known if XHANCE is safe and effective in children.
Important Safety Information
- Do not use XHANCE if you are allergic to fluticasone propionate or any of the ingredients in XHANCE. Get emergency medical care if you get any of these signs of a serious allergic reaction: rash, hives, swelling of your face, mouth, and tongue, breathing problems, or low blood pressure.
- XHANCE can cause nasal problems such as nosebleeds, crusting, sores, hole in the septum, and slow wound healing. You should not use XHANCE until your nose has healed if you have a sore on your nose, have had surgery on your nose, or if your nose is injured.
- XHANCE can cause eye problems including glaucoma and cataracts. You should have regular eye exams when using XHANCE. Call your doctor if you have vision changes while using XHANCE.
- XHANCE may increase the risk of infections and can make certain infections worse. Avoid contact with people who have a contagious disease such as chickenpox or measles while using XHANCE.
- XHANCE can cause reduced production of steroid hormones by your adrenal gland, resulting in tiredness, weakness, nausea and vomiting, and low blood pressure.
- XHANCE can weaken bones (osteoporosis).
- The most common side effects include: nosebleeds, sores (ulcers) in your nose, pain or swelling of your nose or throat, redness in your nose, nasal congestion, sinus infection and headache.
- Tell your medical provider about all your medical conditions and medications that you take. It is especially important to mention if you take antifungal or anti-HIV medicines as they may interact with XHANCE.
These are not all the side effects of XHANCE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Patient Information, Full Prescribing Information and Instructions for Use.